I've have to run the engine to get the brakes bled before,the power assist seems to help..but 90% of the time I just did it with the engine off if I bled them manually...I usually use my home made vacuum bleeder if I'm alone though..
I had no fluid flow to the rear wheel cylinders in my van after I replaced the long 1/4" steel line all the way from the PV to the rear end where it joins the rubber hose..
I could only get the pedal to "pump up" after pumping it like 20 times,then as soon as I let off it,and stepped on it again,it went right to the floor again with zero resistance..
I assumed I ripped the seal in the master cylinder piston,because it master cylinder was actually "stuck" from sitting and it took some foot pressure to get it to break free...so I bought a master cylinder,bled it on the bench ,installed it--and got the exact same results..

..(van has manual brakes BTW)..
Then I took the new steel line off at the rear rubber brake hose and fluid gushed out..hmm..so it was getting that far at least..
I connected it back up and removed both rear wheel cylinder bleeder screws completely--got in the van and pumped the pedal again,it took many pumps before it got pressure and then I held my foot on it,it didn't bleed down at all!..soon as I let off,it was back to zero resistance..not a drop came out of either wheel cylinder!..
I concluded the rear rubber brake hose had somehow sealed itself off,and I found a good used one I had off another GM truck that was identical,I installed it and instantly I had fluid to both rear wheel cylinders,and 5 minutes later it was all bled and working fine again..
All along it was that dam hose !..probably original..
There was probably nothing wrong with the master cylinder,but it was original from 1981,so I felt it was due to be replaced anyway..