By coincidence, I'm presently going through the same thing with my '89 Blazer. A couple of months ago, I changed my front rotors and then found that one of my front calipers was bad so I decided to replace both calipers. I installed Speedbleeders on each caliper and was able to bleed the front brakes by myself with no problems. I didn't touch the rear brakes at the time and all was well. The following week, I decided to take a look at the rear brakes and noticed that one of my wheel cylinders was starting to leak. It wasn't really an issue yet but I decided to replace both wheel cylinders. That is when the fun began.
I installed Speedbleeders on the wheel cylinders thinking that this will be a breeze. When I tried to bleed the right rear wheel, the 1st push on the brake pedal went to the floor as expected. The 2nd push stopped near the top. It turns out that the the piston in my proportioning/combination valve moved so that it then blocked the flow to the rear wheels. I couldn't get it to reset so I decided to replace it with a new one and unfortunately, they are no longer available from GM. So I took my chances with one that I bought off of Ebay. My original prop. valve was the old cast iron version and figured that it was time.
I also bought one of those tools that you insert in to the Prop. valve by removing the brake light switch and inserting the tool to prevent the piston from moving off center. I then proceeded to bleed the right rear wheel again. This time, the brake pedal went to the floor but seemed to have move resistance and I didn't seem to get the flow that I expected. So I then decided to replace my flexible brake lines with Russell stainless steel braided lines. I put the original bleeder screws back in to the rear brake cylinders with thread sealer applied and tried a vacuum bleeder but there was a leak somewhere and all I seemed to suck out was air from the leak.
Next, I am going to try pressure bleeding using my Motive pressure bleeder. The service manual specifies the Kent-Moore master cylinder adapter J-29567. I looked it up on Ebay and found Kent-Moore J-35938 adapters (is part of J-29567). These will insert in to the bottom of the master cylinder and I will then connect them to the Motive bleeder. I'm pretty sure that this will work and will give it a try soon.
Also, on my Blazer, the front of the master cylinder feeds the rear brakes. The rear of the master cylinder feeds the front brakes. Well that was a long but that's my story and I'm sticking to it.