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IMO I would want the hub to be the weak point, thats part of the reason I went with hubs, also I can unlock them for street use of course.
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I prefer not to have a weak point, shock loads from axle failures are known to break locking differentials among other things.
I don't drive my rig on the street anymore but if I did I would have no issues with doing so even locked up front as long as I did it in 2wd. Without input torque my locker doesn't seem to want to lock up, and my high angle driveline can more than take highway speed even at the angle it is operated at.
This is an endless debate but I feel that the slugs are a better choice for the 35 spline outers.
My truck hasn't been out of 4 low since I bought my trailer so I suppose it's not going to matter anyway.