I have a 1996 K2500 with the L29 7.4l 454. I had to finally replace my factory injectors at 170,000+ miles on them. I now only have about 182,000+ on the truck but no problems so far. After doing some reading, it's a pretty common problem, and the other problem is they are pretty expensive, even just for factory replacements. If you get the upgrades (I think they are Bosch) they are really expensive. My motor is 100% stock so I just went with factory upgrades and called it good. Most people change the fuel pressure regulator while you have the plenum (spel?) off since it's right there on the back of the motor next to the injectors. It's worth it to do both at the same time if you are doing it. But to be honest it's not a horrible job.
I have loved my L29 truck. My only problem is the truck is just an extended cab with no door access to the back and I just had my third kid. That's why I just purcahased a 1989 V3500 crew cab that I am going to build into my new tow rig. A part of me wants someone to hit me in my current truck so I can take the money and the motor and swap it into my crew cab, haha. But as of now I am looking for an 8.1 to drop into it. But I think these L29's are sweet motors that with just a little fine tuning can produce a lot.