The TH400 rigs don't get astounding mileage...probably 17 or so. Any of the 700R-4 rigs get low to mid 20's all day long on the highway.
Anyways, more specifically I have two 6.2 rigs here.
#1 is an 83 1/2 ton. 6.2, 700R-4, 3.42's and 235-75-15's. dead stock.
In town, 17.5 mpg - 19 mpg. Freeway cruising at a steady 65 mph it gets 26 mpg.
#2 was my K5. 6.2 SM465/205, 4.56's with 40's. Heavy, horrible aerodynamics, big bias ply tires, no overdrive. In town it'd get 14-15 mpg. On the highway my best ever was 16.5 mpg at 65.
To get good mileage out of them you need to gear em so that cruise rpm on the highway is as near to 1800 rpm as you can get it. This is where the OD tranies really help...you can keep the kind of gearing that makes them move nicely, and still cruise economically. looking at the above examples, the '83 pick-up cruises at 1850 rpm, the K5 cruised at nearer to 2600 rpm.
Every 100 rpm over the magic 1800 loses near enough to one mpg...
Hope that helps.
Rene