You should only need to prime the carburetor if it sits for a couple of weeks, IMO. The gas seems to evaporate out of the float bowls quickly, especially with an open element air cleaner. (Don't remember what your truck has.) My truck with an Edelbrock carb will usually prime itself while cranking, so I just let it build oil pressure while it pulls gas to the carb.
So, how long does it sit when you have to prime the carburetor manually?
I usually pull the choke on fully while cranking and back it off some after it fires up. If it's really cold blooded, you have to listen to what it wants. Lots of black smoke from the exhaust is bad for a gas engine, so don't keep it choked so hard that it smokes black. Warmer air temperatures require less enrichment of the mixture, so less choke, for less time.
It's kinda hard to flood a big block , in my opinion, so give it more choke than you have been and see how it responds. And back the choke off as it increases in RPM. You may be able to hold 1/2 choke for several minutes.
I always let it warm up some before driving away, it depends on engine and ambient air temperatures as to how long. Cold and carburetors don't let you drive away quickly and nicely as soon as you get it running.