I feel like my video should explain some things for the OP pretty well. I tried to go into some detail of the swaps in the video. To summarize, yes you need the ORD big block engine cross-member as the 8.1 will hit your factory cross-member. It's a nice piece, and really not that bad of a price considering. You can use your stock motor mounts in your truck right now, but to be honest, just upgrade them now as I'm sure the 8.1 will chew through an already used stock motor mount. Since you have a 350 in your truck now, just get either ORD's or DIY's competition poly motor mounts for a small block. They will bolt up to the 8.1 just fine and last a long time (and no, they don't have noticeable vibration, at least from what I can tell). I talk about cooling in my video, and talk about fueling, but that has been beat to death as fueling is pretty much the exact same as any other LS swap. To bolt to your SM465 just get an 8.1 specific flywheel (can be picked up anywhere) and your current clutch pack will bolt to the flywheel. You may have to drill out the little mounting holes on the clutch pack a tiny bit as the 8.1 flywheel bolts are metric and just a smidge larger...literally, not a big deal. The stock 8.1 exhaust manifolds will hit your frame, but just get some older 454 manifolds or headers and they bolt up no problem with no real frame clearance problems. Any other smaller detail is outlined in Larry's thread very well and is a great source.
I have always said, if you want to build a BBC, do not go with an 8.1 as yes, the aftermarket is limited which means its expensive. There is stuff out there to build them how you want, but it costs buku bucks. If you are going to build one, just get a 454 as the aftermarket is extensive and about half the price to attain the same desired numbers. But, if you want a simple, good, reliable BBC, an 8.1 is a fantastic option. And yes, in stock form the tune is chocked down quite a bit. A simple tune can get you ~400hp and 500ft lbs...and that is doing nothing to the motor other than tune. For most people's uses, that is plenty and will suit their needs. It's not the perfect solution for really anyone, but I think people are starting to realize that its a fantastic BBC option to get the smoothness/reliability of LS (though it's not really any LS motor), but have found out it's almost easier to swap into some older trucks like our square bodies than 5.3/6.0's (plus the added numbers in stock form too).
To each their own...some people love to hate on the 8.1, some people love it. Just figure out what you want out of your truck and then tell everyone else to suck it

. Though I got a lot of crap from people saying I shouldn't do an 8.1 in my CCLB...now that it's running...everyone wants to buy it off me now...funny how that works