Yeah, a big block with an NV4500 would be a nice combo, and would have a lot more HP. I just checked a few dyno charts, and they both have about the same torque and HP up to around 2500 rpm, but then the 8.1 walks away with over a 100 hp more at 4000 rpm or so, stock 2003 8.1 vs 6.5 at 13 psi. 250 HP is plenty for towing my trailer through the mountains around here, so I'm pretty happy with what I've got now. I can tell you the stock 350 TBI with 200 hp was not quite enough, I'm not a fan of doing 30 mph up a steep hill dragging a 5000 lb trailer. I'm hoping to get close to 20 mpg (15 towing) at 60 or so with 3.73 gears and OD, the k3500 it came out of got around 14 mpg (towing or not, didn't seem to matter much) with 4.56 gears and OD for the last year I drove it, vs around 10 (under 7 towing!) in the Blazer with 4.88 gears and no OD. How about you? :-)
As for the A/C, are you kidding? :-) I'm just relocating the A/C under the dash, not getting rid of it! Converting to the non AC heater on the firewall was actually pretty easy using a section from a donor truck at the junkyard, I just measured about an inch larger all the way around where the A/C unit was on my truck, and cut it out of the donor truck. The same truck provided the under dash A/C unit. The condenser is about half the size of the one in a Suburban, but it should do fine in a Blazer. One slight setback, my N4500 shattered the front input shaft bearing, so I'm waiting for the new one to arrive from the midwest next week. Ouch.