I ran 38's for almost a year with center treads siped. I would estimate 50k miles, but I still sold them with aprox 1/4 tread left. I loved those tires, but I do have one sugestion on the sipes. dont cut the edges of the tread blocks just in the center. Pic below to explain. I had mine siped at a tire shop and they cut all the way across the tread blocks and a buddy of mine (although his where 35's rather than 38's) did his own sipes. in comparison my tires chunked off little bits at the sipes. while his tires didnt and stayed good. We wheeled the same areas all the time. Not that it was a big deal, more of a cosmetic thing.
As far as gearing my axles are 4.56 and I ran a sm465 AND a few worn out 305 engines. (went through 3 freebie engine) That being said I didnt have any problems running 70mph even up hill.
Edit: I also rotated 5 tires about every 2500-3000 miles. So please dont tell me 50k is impossible from TSL's