When my '80 Jimmy still had the stock (ridiculously high) gears I tool a lot of road trips in it. Headed down to FL was great, into the Appalachians sucked. Carb'ed 350, TH350, NP205, 2.73:1
My dad's '85 K10 was always stock and I drove it to make deliveries when I worked for him in the late 80's. It would easily cruise all day at 75, which was as fast as I would go in OH back in the day. Sorry, but I don't remember much about the drivetrain. I know it was a SBC, probably a 305 with either TBI or a carb, TH700R4, NP208, unknown gears
And since you said solid axle I wasn't 100% sure you were just asking about these trucks or just in general about stuff with SFAs. My '96 Jeep Grand Cherokee was an awesome road tripper. Kind of forgotten the details on this one, too. But what I remember- FI 318, 4 spd auto, full time 4WD, 3.73:1
The '85 and the Jeep were both just as comfortable as my '95 Yukon. I don't think IFS is a must have for a road tripper. As long as it's geared right, has OD, quality springs & shocks, and good radial tires you be fine.