I have not, because when it comes to that, I recommend the Holley. The PF4 is a great system, you can't get a quality sequential MPFI system for less cost than the PF4, but when it comes to power adders or tuning hard core stuff, the Holley is just a better tool for the job.
The Edelbrock is not what I consider a 'true" self learning system. It starts with a base tune that you select from a chart that matches your engine combo, and then it can vary that up to a point to compensate, kind of like a factory system with larger learn limits.
The Holley, Fast, etc don't start with a fixed number of tunes to pick from. They start from nearly infinite parameters you enter, create a base map from that, and then can vary it to make up for it. Most of the Holley default learn limits are frequently +/- 100 to 150%, that's a ~300% window, and you could increase that (but I don't recommend it). The Edelbrock is likely +/- 15 - 20%, and you can't change it. This has it's pros and cons. The bad thing is if your engine is out of that window, you have to start over with a different tune and hope its in that window. Most of the time this works. The good thing is, if something goes wrong it won't throw the tune completely out of whack (just 10 - 20%). It's why I recommend turning learning off in the Holley if you have reached a point where it's running great everywhere. You can turn off learning, but leave on closed loop with smaller limits, to compensate for wear and tear, etc. But if you get a big exhaust leak, or a failure of some sort, it won't be trying to learn off incorrect data.
