You can really only tune idle and part throttle timing with a vacuum gauge, and that is more for A/F ratio than timing.
If you go too high on the idle timing sometimes it can "diesel" when you shut it off, meaning it rattles and shakes and runs on for a second or two after key-off because the plugs are too hot and self igniting. This can also be caused by too hot of plugs, poor fuel, overheating, etc.
You won't be able to tune WOT with vacuum because well, there shouldn't be any really, or your throttle body is too small. Sometimes if you locate the vacuum sensor or gauge too close to the air moving by it, it will create a vacuum based on the venturi effect, but that's not the true vacuum of inside the intake.
For part throttle and sometimes WOT, if you ever hear pinging you should definitely back it off a couple degrees at a time until it goes away in that spot.
If you want to simplify getting a good base timing down to seconds instead of 20 minutes, just put it in simple mode (top left) and enter only 3 numbers(idle, cruise, wot) and the Holley will populate the table for you. This is what I would start with on most LS swaps in simple mode...
Then if you take it off simple and put it on 2D table again you can change any of the up to 1024 cells you want.
