OK, let's try this.
The bar that is attached to the rear axle, assuming those are not pivot points and the upper and lower bar are fixed in relation to each other. That bar wants to rotate around the axle centerline which causes the shackle end to go up in an arc.
Now, the shackle will roll fore or aft depending upon the alignment at the time the force is applied. It wants to rotate until it finds the tangent to the arc. That's the sweet spot where the bar lifts on the chassis and plants the tires with negligible front to rear pull on the axle.
So, going back to what I had said earlier, the alignment is almost never perfect so with the shackle pointed down, it would potentially want to rotate the shackle all the way around until its in the upward orientation and hits that tangent. It can't do it because of other limiting factors but it puts a lot of stress on poly joints, bolts, heims whatever. The springs and bar/shackle are fighting the antiwrap bar for lateral control of the axle.
Now, if you have the shackle up to begin with, let's say 90* relative to the bar at rest and again, acknowledging that its never in the perfect spot when you're using the truck and the suspension is in motion. Now apply the force on the same arc, the shackle will be closer to the sweet spot all of the time which in turn diminishes the amount of bind or fight between the springs and bar/shackle.
Easier on parts and more forgiving to set up.