The recipe for this was written quite a while back and hasn't changed much. Truss the housing, run Reid knuckles, RCV shafts, Yukon hubs and an ARB locker. ARB because it gives you a really strong open carrier and if you want the locker, you have one. D44 or 10b base axle doesn't really matter. Drill hubs and rotors for bigger wheel studs and/or swap to 8 lug. Brake options are limited with 6 lug so 8 lug helps there too.
9.5 semi float rear is good, or anything else you want to bolt in there.
I think you're overthinking the wheel thing. Air pressure keeps tires on wheels so just keep air in them. Running a wheel with some extra bead retention like the Method may be in order but if you want the front end to last, keeping it all as light as possible is important and double beadlocks are not that. Neither are 20s. Even a conventional single beadlock is a heavy wheel but may be worth it if you're going to beat the wheels.
All of this has been proven in the desert for decades and works well.
A tire liner type beadlock system (I don't even know what's around anymore) works well for locking beads and provides some measure of "run flat" but they don't beef up the wheel. A conventional outer beadlock does beef up the wheel so once again, if you're going to beat it hard offroad, a conventional beadlock wheel may be in order.